June 7, 2010 - After a decade of controversies, high-dose sublingual immunotherapy (SLIT) has been demonstrated to be a safe and effective therapy option for adults and children with pollen. Studies have clearly shown that there is a dose-response relationship with regard to reduction of symptoms and symptomatic medication intake. Moreover, comparison of different trials indicate the fact that clinical efficacy of SLIT may depend on the duration of therapy. Therefore, for both children and adults, SLIT should only be performed with high-dose preparations providing documented efficacy for a sufficient period ot time to ensure that the best benefit is achieved.
Pediatric Allergy and Immunology. Volume 21 Issue 4p1, Pages 559 - 563. Published Online: 7 Jun 2010
http://www3.interscience.wiley.com/journal/123498108/abstract?CRETRY=1&SRETRY=0
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